The Role of Kidney in Glucose Homeostasis — SGLT2 Inhibitors, a New Approach in Diabetes Treatment

Vasileios Andrianesis; John Doupis


Expert Rev Clin Pharmacol. 2013;6(5):519-539. 

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Expert Commentary

SGLT2 inhibitors are a new strategy for the treatment of type II diabetes mellitus. Their novel mechanism of action is based on the blockage of SGLT2 Na+/glucose co-transporters of renal tubular cells which as a result has glucosuria and excess calories' lose. The accompanying beneficial effects of this phenomenon are the regulation of fasting and postprandial blood glucose levels, the HbA1c reduction, slight body weight loss and reduction of systolic blood pressure. Due to this innovation, the new category of agents can be combined with the existing treatments for type 2 diabetes mellitus (TIIDM) and be an effective weapon for the management of uncontrolled diabetes.