Travel-Associated Illness Trends and Clusters

2000-2010

Karin Leder; Joseph Torresi; John S. Brownstein; Mary E. Wilson; Jay S. Keystone; Elizabeth Barnett; Eli Schwartz; Patricia Schlagenhauf; Annelies Wilder-Smith; Francesco Castelli; Frank von Sonnenburg; David O. Freedman; and Allen C. Cheng; for the GeoSentinel Surveillance Network1

Disclosures

Emerging Infectious Diseases. 2013;19(7):1049-1073. 

In This Article

Abstract and Introduction

Abstract

Longitudinal data examining travel-associated illness patterns are lacking. To address this need and determine trends and clusters in travel-related illness, we examined data for 2000–2010, prospectively collected for 42,223 ill travelers by 18 GeoSentinel sites. The most common destinations from which ill travelers returned were sub-Saharan Africa (26%), Southeast Asia (17%), south-central Asia (15%), and South America (10%). The proportion who traveled for tourism decreased significantly, and the proportion who traveled to visit friends and relatives increased. Among travelers returning from malaria-endemic regions, the proportionate morbidity (PM) for malaria decreased; in contrast, the PM trends for enteric fever and dengue (excluding a 2002 peak) increased. Case clustering was detected for malaria (Africa 2000, 2007), dengue (Thailand 2002, India 2003), and enteric fever (Nepal 2009). This multisite longitudinal analysis highlights the utility of sentinel surveillance of travelers for contributing information on disease activity trends and an evidence base for travel medicine recommendations.

Introduction

International travel is markedly increasing. In 2010, an estimated 940 million tourists arrived at international destinations, more than twice the 435 million in 1990.[1] Trips to developing regions have risen from 31% of all travel in 1990 to 47% in 2010, and trips to the Asia–Pacific region, Africa, and the Middle East have doubled in the past decade.[1] Reasons for travel have also changed; from 1990 to 2010, trips for tourism decreased from 56% to 51%, and trips by those with ties to the destination country (travel for the purpose of visiting friends and relatives) increased from 20% to 27%.[1,2]

More than half of international travelers to developing countries become ill during their trip, and ≈8% seek medical care for a travel-associated illness either during or after travel.[3] Changes in travelers' illnesses over time would be expected to reflect changing patterns of global travel destinations, changes in local disease epidemiology in regions visited, and/or availability of preventive measures such as vaccination and chemoprophylaxis. To examine illness trends and clusters among travelers, we analyzed multisite longitudinal data collected by GeoSentinel sites during 2000–2010.

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