Food Protein-Induced Enterocolitis Syndrome

From Practice to Theory

Stefano Miceli Sopo; Monica Greco; Serena Monaco; Salvatore Tripodi; Mauro Calvani


Expert Rev Clin Immunol. 2013;9(8):707-715. 

In This Article

First Criterion: 'Age Younger Than 9 Months at Initial Presentation'

FPIES appears for the first time before the ninth month of life if the patient consumes the culprit food before that age. This statement is certainly true for CM FPIES, while there are some doubts about solid culprit foods, such as fish. In fact, fish FPIES can occur after the ninth month and even after the twelfth month. Some episodes have been reported even in adolescents and adults and the culprit food were crustaceans. So this criterion should not be strictly applied, but our limit of 2 years seems to be more appropriate.