Food Protein-Induced Enterocolitis Syndrome

From Practice to Theory

Stefano Miceli Sopo; Monica Greco; Serena Monaco; Salvatore Tripodi; Mauro Calvani


Expert Rev Clin Immunol. 2013;9(8):707-715. 

In This Article

FPIES Prognosis

How long does a dietary restriction have to be carried out ? When do baby patients recover from FPIES? The majority of children achieve tolerance at the age of 3 years and only a few of them manifest this syndrome longer. In our series there is one 5-year-old child affected by active soy FPIES, while another one, who is six years old, suffers from active CM FPIES. In our experience,[5] in cases of CM FPIES, tolerance was achieved at a mean age of 30 months; we also observed that children with CM FPIES have 60% probability of passing an OFC with the culprit food at 18 months. Other authors[4,23] reported even lower ages; according to Hwang et al.[23] there are many chances to be cured at the age of 1 year. Regarding FPIES induced by other foods, it is not possible to predict anything specific, unless the probability of achieving tolerance increases from the third year of life. We are used to performing an OFC year by year, until tolerance is achieved. Atypical cases of FPIES (so defined for their late insurgence, past the ninth month, and/or for the presence of specific culprit food IgE) could last more than typical ones and even run into an unusual destiny, as Micol's history teaches.