Preventing or Reversing Immunosenescence

Can Exercise Be an Immunotherapy?

Adriana L de Araújo; Léia CR Silva; Juliana Ruiz Fernandes; Gil Benard

Disclosures

Immunotherapy. 2013;5(8):879-893. 

In This Article

Tregs & Immunosenescence

There are scarce data regarding the ability of natural Treg cells to regulate/suppress immune responses with aging. Studies with a mouse model of aging showed significantly enhanced percentages of peripheral CD4+CD25 Treg cells in aged mice and changes in the TCR repertoire and functionality of the CD4+CD25+ lymphocytes.[87] By contrast, in a single study in humans, an increase in age was associated with an augmented CD4+CD25+ lymphocyte number without changes in function when compared with young individuals.[88]

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