Selective Estrogen Receptor Modulators for BPH

New Factors on the Ground

M Garg; D Dalela; D Dalela; A Goel; M Kumar; G Gupta; S N Sankhwar


Prostate Cancer Prostatic Dis. 2013;16(3):226-232. 

In This Article


With the discovery of ERβ-specific SERMs, our knowledge about the basic pathophysiology and underlying cellular signaling mechanism has been potentiated and this has opened up new pathways in pharmacological management of BPH. There are various preclinical studies in literature that support the rationale for evaluation of clinical application of SERM alone or in combination with existing androgen blockade for the management of BPH. ERβ appears to mediate beneficial effects by favorably altering the growth factor milieu, and exerting anti-proliferative, anti-inflammatory and pro-apoptotic effects.