Oxidative Stress in Prostate Cancer

Changing Research Concepts Towards a Novel Paradigm for Prevention and Therapeutics

A Paschos; R Pandya; W C M Duivenvoorden; J H Pinthus


Prostate Cancer Prostatic Dis. 2013;16(3):217-225. 

In This Article

Conclusive Remarks

Negative results from prevention studies suggest that there is more to be hypothesized and studied in the field of oxidative stress and PC and that a simplistic approach of nutritional or supplemental chemoprevention is doomed to fail without a thorough understanding of the molecular biology related to oxidative stress and in particular its relationships with individual genetic and epigenetic factors. The intricate relationship between oxidative stress and PC contributes to PC development and progression. In particular, the connection between H2O2 signaling, oxidative protein alterations and activation of growth pathways emerges to be crucial and could bear tremendous potential for the development of multilevel strategies for novel cancer therapy options. Further multidisciplinary research approaches are required to dissect the antioxidative and oxidative cellular relationships and understand this intricate interplay at the molecular level. Moreover, advances in analytical chemistry and nutritional research may provide the translational basis for the molecular understanding of the mechanism of carcinogenesis and other ROS-associated diseases.

Finally, oxidative stress measurements remain a challenge due the volatility of the compounds and variability from a variety of different pathways and mechanisms involved. Thus currently, although strong correlations are seen between oxidative stress and PC, clinical translations are lacking. An evolving change in concepts and research directions in the field of redox biology are expected to result in more rationalized future applications of related therapeutics and diagnostics.