Oxidative Stress in Prostate Cancer

Changing Research Concepts Towards a Novel Paradigm for Prevention and Therapeutics

A Paschos; R Pandya; W C M Duivenvoorden; J H Pinthus

Disclosures

Prostate Cancer Prostatic Dis. 2013;16(3):217-225. 

In This Article

Oxidative Stress Markers in PC

Given the central role of androgens in the induction of prostatic oxidative stress and their role in prostate carcinogenesis, the question arises whether prostatic oxidative stress can be predicted by circulating androgen levels or by systemic markers of oxidative stress? This is a particularly important and clinically relevant question, as the mass application of antioxidative micronutrients for the prevention of PC has failed clinically[81] and as such individualization of prevention strategies, using surrogate markers for prostatic oxidative stress, may be more logical. Unfortunately, measurements of oxidative stress-related markers in blood do not correlate to PC development.[96] However, studies in rats demonstrated that circulating testosterone levels do correlate with prostatic oxidative stress.[37] On the other hand, variability in prostatic oxidative stress exists between individuals, even at a constant castrated level of serum testosterone. This probably reflects differential effect of androgens on the androgen receptors in target organs.[29] In contrast, the oxidative stress status in hair follicles and salivary glands, exocrine structures that are partially regulated by androgens, was found to correlate closely with the prostatic oxidative stress status on an individual basis.[29] Although further studies in PC patients are required, this may suggest that the oxidative stress status in these two tissues can be used as a surrogate marker for individualization of PC prevention and therapeutics.

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