Periodontal Disease and Rheumatoid Arthritis

The Evidence Accumulates for Complex Pathobiologic Interactions

Clifton O. Bingham III; Malini Moni


Curr Opin Rheumatol. 2013;25(3):345-353. 

In This Article

Oral Health in Rheumatoid Arthritis

A number of oral manifestations have been described in rheumatoid arthritis patients. These include the well recognized association with Sjogren's and xerostomia, TMD,[2] methotrexate-induced ulcers, and an increasing emphasis on periodontal disease.[3] Oral mucosal involvement in autoimmune diseases, including rheumatoid arthritis, occurs with high frequency.[4] Symptomatic xerostomia and secondary Sjogren's are not uncommon in rheumatoid arthritis patients, with recent studies[5,6] providing prevalence estimates of between 3 and 30%, depending on the definition. Recently published classification criteria for primary Sjogren's syndrome by the American College of Rheumatology and the Sjogren's International Collaborative Clinical Alliance Cohort[7] will facilitate more accurate descriptions of Sjogren's prevalence, a condition with considerable impact on overall health-related quality of life.[8,9] Whether secondary Sjogren's in rheumatoid arthritis is associated with an increased periodontal disease remains unclear; some studies[10–12] have suggested increased periodontal disease and gingivitis in Sjogren's, but others have not.