The Lyme Disease Debate

Host Biodiversity and Human Disease Risk

Sharon Levy

Disclosures

Environ Health Perspect. 2013;121(4):a120-a125. 

In This Article

Forest Fragmentation and Biodiversity

Ostfeld suggests that fragmentation of forest habitat plays an important role in facilitating the spread of Lyme disease. His argument is based on the notion of nested biodiversity: Large swaths of habitat house diverse animal communities, and as forests are cleared for human use, species disappear from the remaining isolated scraps of habitat in a predictable sequence. This pattern has been documented on oceanic islands and other isolated habitats.[33] But whether it applies to the forests of the northeastern and midwestern United States, where Lyme disease is most prevalent, remains a contentious issue.

Ostfeld's work shows that the white-footed mouse, a powerful amplifier of Lyme disease risk, persists in small fragments of forest after other species disappear.[34] He argues that hosts resistant to tick infestation and Bb infection are far more sensitive to human disturbance. Yet raccoons and opossums, which appear to be among the most effective dilution hosts for Bb, are common in urban and suburban areas. Studies from Illinois and California showed these animals thrived in remnants of forest and moved easily across farm fields.[33,35] The California study noted that opossums prefer intensely disturbed habitats.

"If you fragment the forest, you still have all the main hosts for Bb," says Maria Diuk-Wasser, a disease ecologist at Yale School of Public Health. "The major hosts are all human-adapted. Raccoons and opossums are present in people's backyards."

Diuk-Wasser is now collaborating with Fish on a study that tests the hypothetical link between biodiversity and human risk of Bb infection in new ways. Among the human residents of Block Island, off the coast of Rhode Island, Lyme disease is a common affliction. The island has low mammalian biodiversity; the only tick hosts present there are deer, white-footed mice, and birds. The researchers are trapping mice, collecting the ticks that infest them, and testing them for Bb infection. They're cooperating with colleagues who have been collecting data on human cases of Lyme disease for years. The results from Block Island will be compared with those from a site on the Connecticut mainland, where a full complement of vertebrate tick hosts is present—and Lyme disease is also endemic.

If the dilution hypothesis holds, the number of infected nymphal ticks should be much higher on Block Island than on the mainland. The Yale investigators are also collecting ticks from backyards to directly examine the interface between humans and vectors of Bb. Fish, a critic of Ostfeld's model of Bb ecology, does not expect to find simple correlations. "Community composition does affect Lyme disease ecology, but it's not a rule of thumb that more biodiversity means less risk to people," he says.

Both Ostfeld and Fish have coauthored studies that found a correlation between the size of forest habitats and the risk of Lyme disease. In surveys of 14 forest fragments ranging in size from 0.7 to 7.6 hectares, Ostfeld's team found that white-footed mice were abundant in small forest patches and that the density of infected nymphal ticks was highest in the smallest patches (less than 1.2 hectares, comparable to the area inside an athletic track).[34] Fish and his colleagues found a similar pattern in woodland habitats near Lyme, Connecticut, but noted that despite the higher number of infected ticks in fragmented habitats, the rate of human infections was lower there.[36] This was so, the group concluded, because as woods were cleared for suburban development, the remaining habitat patches became few and far between, so that most people in the area never got near enough to a forest fragment to contact an infected tick.

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