The Association Between Celiac Disease and Eosinophilic Esophagitis in Children and Adults

Michael J Stewart; Eldon Shaffer; Stephan J Urbanski; Paul L Beck; Martin A Storr


BMC Gastroenterol. 2013;13(96) 

In This Article


The incidence of autoimmune diseases of the gastrointestinal tract is increasing. Although no genetic link between CD and EoE has been identified, this population-based study confirms the association between EoE and CD. The estimated risk of each condition is increased 50 to 75-fold in those pediatric patients diagnosed with the alternative condition. Furthermore, our data suggest that this significant association may be limited to the pediatric age group; no adults diagnosed with both conditions were identified. This unexpected finding highlights the urgent need for prospective studies in both children and adults. The major implication of this study is that the concomitant diagnosis of these conditions should be considered in pediatric patients with upper gastrointestinal symptoms.