Women With Chronic Hepatitis C Virus Infection

Recommendations for Clinical Practice

Mary Jane Burton, MD; James B. Brock, MD; Stephen A. Geraci, MD


South Med J. 2013;106(7):422-426. 

In This Article


The natural history of HCV infection differs between women and men. Women are more likely than men to clear acute HCV infection. With chronic HCV infection, women experience a slower progression to cirrhosis and are less likely than men to develop hepatocellular carcinoma. Accelerated disease progression occurs in postmenopausal women; older women also have lower rates than younger women of SVR to pegylated interferon and ribavirin. Infected women of childbearing age should be educated about the risks of perinatal HCV transmission and the potential teratogenicity of current treatment regimens. All women with HCV should be counseled on the effects of alcohol and obesity on the progression of liver disease.