Modern Management of Ocular Surface Squamous Neoplasia

Michael Tsatsos; Carol L Karp


Expert Rev Ophthalmol. 2013;8(3):287-295. 

In This Article

Abstract and Introduction


Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjuctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. A number of risk factors, including genetic predisposition, immunosuppression, HPV infection, ultraviolet exposure and smoking, have been associated with the appearance of OSSN. The authors discuss the recent advances in the management of OSSN, and describe surgical techniques and medical approaches to treat this disease. The authors believe that ultra-high-resolution optical coherence tomography will provide invaluable help in the diagnosis of surface lesions and their recurrences in the near future.


Treatment of ocular surface squamous neoplasia (OSSN) has changed significantly in the past 20 years due to a greater understanding of the disease, improved diagnostic capabilities and a shift towards the medical management of these tumors. There is now an increased awareness of its association with solar exposure and conditions such as xeroderma pigmentosa and HIV infection. The aim of this review is to describe the various options for the treatment of ocular surface neoplasia and suggest the best approach for the management of OSSN and its recurrences.