Nutrient Supplementation

Improving Male Fertility Fourfold

Cesar Mora-Esteves, MD; David Shin, MD


Semin Reprod Med. 2013;31(4):293-300. 

In This Article


Menevit is an oral antioxidant supplement consisting of vitamin C, vitamin E, zinc, folic acid, lycopene, garlic oil, and Se. In a prospective, randomized, double-blind trial involving 60 couples with severe male-factor infertility, a daily oral Menevit tablet taken for 3 months before the partner's in vitro fertilization cycle improved the viable pregnancy rate (38.5% of transferred embryos) compared with a placebo group (16% of transferred embryos).[104]

Coenzyme Q10 (CoQ-10) is found endogenously in the sperm midpiece. It recycles vitamin E, controls its prooxidant capability, and is involved in energy production.[105] In vitro incubation of semen samples of infertile men with 50 mM of CoQ-10 significantly increased sperm motility. Oral supplementation with 60 mg of CoQ-10 in these infertile men was seen to improve fertilization rate without affecting semen parameters.[106] Catalase is another antioxidant that should be further investigated for its ability to detoxify both intracellular and extracellular hydrogen peroxide to water and oxygen.[107] Other compounds involved in the regeneration of antioxidant stores, such as lipoic acid, may also be beneficial to enhance the effects of vitamins C and E as well as GSH.[108]