Avoiding Toxins Including Spermatotoxic Medications

Gillian Stearns, MD; Paul J. Turek, MD


Semin Reprod Med. 2013;31(4):286-292. 

In This Article


Given that cholesterol is a precursor substrate molecule for steroid hormones such as testosterone, it has been hypothesized that statins could impede male fertility.[40] However, a year-long study of beagles on statins showed no effects on reproductive hormonal function or semen quality.[41] A trial in humans also showed that despite lowering of cholesterol, reproductive hormone levels remained constant.[40] In addition, no changes in sperm motility or ejaculate volume have been noted in patients taking statins.[40]