Placental-Mediated Pregnancy Complications
Adverse pregnancy outcomes such as recurrent loss, preeclampsia, fetal growth restriction and placental abruption are not infrequent in the general population.[20,21] Although the most compelling data for a link between thrombophilia and adverse pregnancy outcomes are derived from studies in women with antiphospholipid antibodies (APLAs), some research also suggests an association between adverse pregnancy outcomes (and their severity) and hereditary thrombophilias.[9,22] Hypercoagulability and thrombosis is unlikely to be the sole mechanism by which thrombophilia increases the risk of pregnancy complications. It is more likely that effects on trophoblast differentiation and early placentation may be involved through as yet unknown mechanisms.[23–26]
Expert Rev Hematol. 2013;6(3):287-300. © 2013 Expert Reviews Ltd.