Implementation of pediatric immunization against organisms such as Haemophilus influenzae and Streptococcus pneumoniae has led to a decrease in disease in vaccinated children and also indirectly protected unvaccinated children and adults. For example, after introduction of the seven-valent pneumococcal conjugate vaccine, invasive pneumococcal disease declined not only in vaccinated children but also in unvaccinated children and adults. Likewise, indirect protection has been observed in unvaccinated children and adults with implementation of infant rotavirus vaccination. We will discuss the benefits and limitations of indirect protection of the herd, observed after implementation of widespread rotavirus immunization in the USA.
Expert Rev Vaccines. 2013;12(6):585-587. © 2013 Expert Reviews Ltd.