Current Update on the Treatment of Genital Warts

Valerie R Yanofsky; Rita V Linkner; David Pompei; Gary Goldenberg


Expert Rev Dermatol. 2013;8(3):321-332. 

In This Article

Expert Commentary

EGW occur as a result of underlying infection with HPV, and are considered among the most common sexually transmitted diseases affecting the general population. Approximately 90% of wart lesions are caused by infection with low-risk HPV types 6 and 11 only rarely progress to cancerous lesions. Warts associated with the high-risk HPV types 16 and 18 may be predisposed to oncogenic transformation. Multiple different therapy modalities exist, ranging from topical treatments to surgical and immunomodulatory interventions, and these can differ quite dramatically with respect to cost, duration, dosing schedules and adverse effects. As of yet, no single therapy has emerged as significantly superior with respect to overall efficacy and wart clearance in both the short and long term. Selection of a given treatment is often patient dependent, and reflects both the needs and the desires of the individual. EGW and HPV infections remain a significant public health concern, with a remarkably high prevalence of disease and a lack of adequate therapy. This emphasizes the importance of routine HPV vaccination, which may play a powerful role in reducing the burden of disease by preventing viral infection and transmission.