Fecal Microbiota Transplantation

Breaking the Chain of Recurrent C. difficile Infection

Amy Marinski, MSN, RN, CCRN, CNL


Am Nurs Today. 2013;8(6) 

In This Article

Fecal Donor Selection

FMT requires a healthy donor to provide stool for transplantation. Donors are recommended by the patient; they may be healthy relatives or close friends. Potential donors must undergo an extensive interview to assess lifestyle and health history, as certain laboratory tests may not detect early infection. Exclusionary criteria include tattoos or body piercings within the last 6 months, a history of incarceration, high-risk sexual behaviors, communicable illnesses or antibiotic treatment within the past 3 months, and such GI conditions as irritable bowel syndrome or chronic diarrhea. Donor stool is tested extensively for pathogens, including C. difficile, ova and parasites, Helicobacter pylori, Giardia, and Cryptosporidium. Donor blood is tested for human immunodeficiency virus, syphilis, and hepatitis A, B, and C.

For 5 days before stool collection, donors must refrain from eating foods to which the recipient may be allergic. They should notify the physician if they become ill with fever, diarrhea, or vomiting between screening time and donation. They are given a urine collection hat, a stool specimen cup prelabeled with their name, a tongue depressor, and a biohazard bag for transporting stool to the hospital.