José G. Merino, MD, MPhil


June 18, 2013

In This Article

Data Blitz: The Scientific Presentations

During the second half of the session, several researchers presented their findings. Some of these took place during the moderated poster session, and others as an oral "data-blitz" brief presentation.

Use of Biomarkers to Predict Risk for Stroke

Mitchell Elkind and colleagues[1] analyzed data from 4189 adults enrolled in the Cardiovascular Health Study to assess whether biomarkers of cardiac structure and injury (pro-B-type natriuretic peptide and highly sensitive cardiac troponin) can predict risk for subsequent stroke. They found that patients with higher levels of these biomarkers had a higher risk for stroke; doubling the concentration of either biomarker increased the risk for stroke by 13%-16%. Of interest, the results did not change after adjustment for a history of atrial fibrillation or heart failure, suggesting that these markers provide prognostic information beyond that of a history of these conditions.

Christopher Anderson and colleagues did a multicenter association study[2] to determine whether common variations in genes encoding the mitochondrial oxidative phosphorylation (OXPHOS) apparatus influence the risk for stroke. They found associations between variations of these genes and ischemic (particularly small-vessel) and hemorrhagic stroke. The observed associations suggest that OXPHOS gene variations may influence small-vessel pathobiology. Further studies to analyze these associations may shed light on the way in which mitochondrial dysfunction leads to stroke.