Long-term Effects of Hysterectomy

A Focus on the Aging Patient

Catharina Forsgren; Daniel Altman


Aging Health. 2013;9(2):179-187. 

In This Article

Neurodegenerative Diseases

The long-term cognitive effects of hysterectomy and oophorectomy remain controversial. Some studies indicate that hysterectomy and oophorectomy may have harmful brain effects via direct endocrinological mechanisms,[110] and estrogen deficiency appears to play a key role in these associations.[110] Other studies indicate that use of hormone replacement therapy subsequent to hysterectomy may increase the risk of neurodegenerative diseases such as Parkinson's disease.[111] The subject is poorly investigated and there is no consensus on the possible cognitive effects of hysterectomy.