Long-term Effects of Hysterectomy

A Focus on the Aging Patient

Catharina Forsgren; Daniel Altman


Aging Health. 2013;9(2):179-187. 

In This Article

Cancer Disease

Hysterectomy has been associated with several neoplasms including thyroid cancer, renal cancer and bladder cancer, but the associations are generally weak and inconsistent. Renal cell carcinoma is the eighth most common cancer among women in the USA, and composes the majority of the new cases of renal parenchyma adenocarcinoma.[105] Lee et al. from the Nurses' Health Study observed no clear associations between hysterectomy and renal cell carcinoma,[106] but others suggest the opposite.[107,108] Altman et al. demonstrated that hysterectomy for benign indication was associated with a significant long-term risk of renal cell carcinoma (hazard ratio: 1.5; 95% CI: 1.3–1.7) among women with hysterectomy versus women without hysterectomy. The risk of renal cell carcinoma was age dependent, and the highest risk was found within 10 years of surgery among women who underwent hysterectomy at 44 years of age or younger (hazard ratio: 2.36; 95% CI: 1.49–3.75).[108] The mechanisms by which hysterectomy increases subsequent renal cell carcinoma risk are undecided but may include catecholamine, iron metabolism, hormonal changes and urine dynamics.[107–109]