Neuroimaging in the Evaluation of Epilepsy

Naymee J. Velez-Ruiz, MD; Joshua P. Klein, MD, PhD2


Semin Neurol. 2012;32(4):361-373. 

In This Article


Neuroimaging has provided an extraordinary insight into the pathologic substrate of epilepsy, which is essential for diagnosis, treatment, and determination of prognosis in epileptic patients. MRI is the primary imaging modality for the evaluation of patients with seizures. It allows for the reliable identification of the most common underlying pathologies in epilepsy, including HS, MCD, low-grade tumors, abnormalities associated with neurocutaneous disorders, CA, and sequelae of TBI. Concordance of findings from structural MRI and functional techniques, such as PET, SPECT, MEG, fMRI, and of course EEG, is of great importance in the presurgical evaluation of patients with medically refractory epilepsy.