Impact of Metabolizing Enzymes on Drug Response of Endocrine Therapy in Breast Cancer

Pilar H Saladores; Jana C Precht; Werner Schroth; Hiltrud Brauch; Matthias Schwab


Expert Rev Mol Diagn. 2013;13(4):349-65. 

In This Article

Conclusion of DME Impact on Clinical Outcome of AI Therapy

So far, evidence supporting an impact of genetic variation of DMEs on AI therapy outcome in breast cancer patients is limited. Further studies on AI pharmacogenomics regarding efficacy as well as AI-related adverse drug reactions are required to better understand interindividual variability of drug response and to identify patients at risk.