Impact of Metabolizing Enzymes on Drug Response of Endocrine Therapy in Breast Cancer

Pilar H Saladores; Jana C Precht; Werner Schroth; Hiltrud Brauch; Matthias Schwab


Expert Rev Mol Diagn. 2013;13(4):349-65. 

In This Article

AI Metabolism & the Role of Polymorphisms in DMEs

Although the role of DMEs for AI outcome is less investigated compared with tamoxifen, initial studies addressed pharmacogenetic relationships that may indicate potential clinical implications. Inspired by the CYP2D6 tamoxifen pharmacogenetic paradigm, it is of high interest to understand the possible role of DME genetic variants involved in AI metabolism. However, this is by far a more complex issue because letrozole, anastrozole and exemestane follow different metabolic pathways.