The Pathophysiological and Pharmacological Basis of Current Drug Treatment of Migraine Headache

Doodipala Samba Reddy


Expert Rev Clin Pharmacol. 2013;6(3):271-288. 

In This Article

STM: Moderate-to-Severe Migraine

Moderate-to-severe migraine attacks are generally treated with ergot alkaloids or triptans (Table 3). Ergot alkaloids have been used for many years for migraine but appear less effective than triptans.[63–75] Triptans are the most effective drugs for acute migraines.[76–78] Specific STM agents such as the triptans and ergot preparations (ergotamine and dihydroergotamine) promote relief of migraine but no other pain. These agents appear to act through the serotonin system.