Agent Orange Tied to Aggressive Prostate Cancer Risk

May 13, 2013

By Genevra Pittman

NEW YORK (Reuters Health) May 13 - Men who were exposed to Agent Orange chemicals during the Vietnam War are at higher risk for high-grade prostate cancer than unexposed veterans, researchers have found.

Furthermore, those who served where the herbicide was used were diagnosed with cancer about five years earlier than other men, on average, in the new study.

"This is a very, very strong predictor of lethal cancer," said Dr. Mark Garzotto, who worked on the study at the Portland Veterans Affairs Medical Center in Oregon.

"If you're a person who's otherwise healthy and you've been exposed to Agent Orange, that has important implications for whether you should be screened or not screened," he told Reuters Health.

Agent Orange - named after the giant orange drums in which the chemicals were stored - was used by the U.S. military to destroy foliage, mainly in southern Vietnam. It was often contaminated with a type of dioxin, a potently carcinogenic chemical.

The Vietnam Red Cross Society has estimated that up to one million Vietnamese suffered disabilities or health problems as a result of Agent Orange, including children born with birth defects years after their parents were exposed.

Past research has also suggested that U.S. veterans who served where Agent Orange was used are at an increased risk of lymphoma and certain other cancers, including prostate cancer.

For the new study, to see whether exposure was more closely linked to slow-growing cancers or aggressive tumors (i.e., high-grade cancers with Gleason score of at least 7), the researchers analyzed medical records of 2,720 veterans who were referred to the Portland VA for a prostate biopsy.

About one in 13 of those men had been exposed to Agent Orange during the Vietnam War, according to their VA intake interviews.

One third of all men in the study were diagnosed with prostate cancer, about half of which were high-grade cancers.

After adjustment for age, race, weight and family history of cancer, men with Agent Orange exposure were 52% more likely than unexposed men to have any form of prostate cancer.

Separating out different types of tumors showed the herbicide was not linked to an increased risk of low-grade cancer. But it was tied to a 75% higher risk of aggressive prostate cancer, the study team reported Monday in Cancer.

"The increase in the rate of cancers was almost exclusively driven by the potentially lethal cancers," said Dr. Garzotto.

More research is needed to figure out exactly why that is, he said, but in the meantime, veterans who were exposed to Agent Orange should discuss that with their doctors.

But Dr. Arnold Schecter, from the University of Texas School of Public Health's Environmental and Occupational Health Sciences Program in Dallas, said there's a "big problem" with just asking veterans if they were exposed to Agent Orange or served in an area where it was sprayed.

"Of those most heavily exposed in the military as best we know, only a relatively small percentage of them had elevated dioxin from Agent Orange in their blood when tested by (the U.S. Centers for Disease Control and Prevention)," he told Reuters Health.

Dr. Schecter said that in Vietnam, people who have high levels of that type of dioxin in their blood live in places where the chemical has become integrated into the food supply - or were sprayed directly with Agent Orange.

Another researcher who has studied the effects of Agent Orange agreed that not having blood dioxin levels is a drawback, but said the findings are consistent with past research and general thinking about the chemical.

"Almost all studies have implicated that men with Agent Orange (exposure) either have higher-grade prostate cancer or a more aggressive clinical course," said Dr. Gregory Merrick, head of Wheeling Hospital's Schiffler Cancer Center in West Virginia, who also wasn't involved in the new research.

But, he added, as long as men are getting into the VA system and getting regular evaluations and treatment for cancer, Agent Orange exposure "is not a death sentence by any means."


Cancer 2013.


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