Consumption of Coffee Associated With Reduced Risk of Liver Cancer

A Meta-Analysis

Li-Xuan Sang; Bing Chang; Xiao-Hang Li; Min Jiang


BMC Gastroenterol. 2013;13(34) 

In This Article


Primary liver cancer is a common malignancy worldwide. It is the fifth most common cancer in men and the cause of a third of male cancer deaths. It is the eighth most common cancer in women and the sixth most common cause of female cancer deaths.[1] Chronic infection with hepatitis B or C viruses and alcohol consumption are considered the most important risk factors for liver cancer.[2–5] A large number of epidemiological studies indicated that environmental factors can affect the risk of liver cancer, but the role of dietary factors in tumorigenesis has not yet been determined.[6–8] Analysis of environmental factors that may be associated with liver cancer has become a popular research topic in recent years.

Coffee contains many biologically active components, some of which may have anti-tumor effects. Epidemiological studies have reported inconsistent findings on the association between coffee and liver cancer. We therefore carried out a meta-analysis of prospective cohort studies and case–control studies in order to clarify the association between coffee consumption and liver cancer.