Atypical Lymphoid Proliferations

The Pathologist's Viewpoint

Mahmoud Rezk Abdelwahed Hussein

Disclosures

Expert Rev Hematol. 2013;6(2):139-153. 

In This Article

Conclusions

Lymphoid proliferations include benign (lymphoid hyperplasia and lymphadenitis) equivocal and malignant (lymphoma) conditions. AtLP have morphologic features equivocal between the benign and malignant extremes. They are conditions in which distinction between benign and malignant diagnosis is challenging. Morphologically, they have a worrisome cytoarchitectural features. Common morphologic patterns of AtLP include: AtLP with follicular pattern, AtLP rich in Reed–Sternberg-like cells and AtLP composed predominantly of T cells. Diagnosis of AtLP depends on the constellation of clinical, morphologic and molecular findings.

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