The Association Between Acetaminophen and Asthma

Should Its Pediatric Use Be Banned?

Antonio Martinez-Gimeno; Luis García-Marcos


Expert Rev Resp Med. 2013;7(2):113-122. 

In This Article

Review of the Bradford Hill Criteria

As an overview to the case against acetaminophen as a wheezing disorders promoter, the authors can check the nine classic criteria proposed by Bradford Hill in 1965 to differentiate among association and causation.[27] Table 1 shows that most of the criteria have been fulfilled but the most important from the practicing pediatrician's point of view, that is, removal of exposure prevents disease, has been evaluated satisfactorily in only one clinical trial in wheezing children in the short term[15] but has not been satisfactorily addressed to date in the general pediatric population.