Gout and Its Comorbidities

Implications for Therapy

Lisa K. Stamp; Peter T. Chapman


Rheumatology. 2013;52(1):34-44. 

In This Article


Patients with gout frequently have associated medical conditions that may enhance the development of gout and make management more challenging. The choice of therapy for both acute gout and gout prophylaxis needs to be tailored according to the individual patient's comorbidities and their co-prescribed medications. Many cardiovascular medications result in an increase in SU, and in patients with troublesome or refractory gout, consideration should be given to using alternative therapies with no deleterious or possibly beneficial effects on SU. Sustained urate reduction to <0.36 mmol/l is critical for the long-term management of gout. There is now more choice regarding ULT and better data on the optimal use of established therapies such as allopurinol.

Disclosure statement: The authors have declared no conflicts of interest.