FPIES: The 'Other' Food Allergy

Anna Nowak-Wegrzyn, MD


April 03, 2013

Editor's Note:
Medscape invites you to challenge your knowledge of food protein-induced enterocolitis syndrome (FPIES) in children. The results of the survey questions that appear throughout this interactive case challenge, developed in conjunction with the researchers at the Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, will inform the development of future educational offerings and further understanding of this often misdiagnosed condition.

What Is FPIES?

FPIES is a potentially severe, non-immunoglobulin (Ig)E, cell-mediated, gastrointestinal food hypersensitivity typically provoked by cow's milk (CM) or soy. Less commonly, it may result from solid food ingestion, such as rice, oat, fruits, or vegetables.[1] Prevalence in the United States is not known. However, a study from Israel determined that in a large birth cohort of over 13,000 infants, 0.34% developed FPIES to milk in the first year of life, comparable to the 0.5% of infants who developed an IgE-mediated milk allergy.[2]