Psoriasis and Susceptibility to Other Autoimmune Diseases

An Outline for the Clinician

Faisal R Ali; Richard B Warren


Expert Rev Clin Immunol. 2013;9(2):99-101. 

In This Article


Psoriasis is a chronic inflammatory disease affecting 2% of the adult population. Common cutaneous manifestations include well-defined red plaques with a silvery-white scale, typically distributed symmetrically on extensor surfaces.[1] The multisystem nature of psoriasis, namely its association with a seronegative arthropathy and the metabolic syndrome, is now well established. During the last decade, it has become increasingly recognized that psoriasis is part of an autoimmune spectrum in which diverse diseases share common underlying genetic susceptibility loci, molecular mechanisms and treatment modalities. We will review existing evidence and explore the implications this may have to the practicing clinician.