Optical Coherence Tomography and Fundus Autofluorescence Imaging in Uveitis

Andre J Witkin; Rajiv Shah; Sunir J Garg


Expert Rev Ophthalmol. 2013;8(1):89-99. 

In This Article

Abstract and Introduction


The current role of optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging in the diagnosis and management of uveitis is summarized in this article. OCT can be useful to detect and monitor cystoid macular edema and epiretinal membrane, two findings that are very common in intermediate, posterior and pan-uveitis. Both OCT and FAF demonstrate unique findings in several forms of posterior uveitis including birdshot chorioretinopathy, multiple evanescent white dot syndrome, acute posterior multifocal placoid pigment epitheliopathy, acute zonal occult outer retinopathy, multifocal choroiditis and Vogt–Koyanagi–Harada disease. Advances in OCT have allowed detection of alterations in retinal microstructure (spectral-domain OCT) as well as variations in choroidal thickness (enhanced-depth imaging OCT). With new advances in imaging, OCT and FAF have been shown to be helpful in understanding the pathophysiology of and differentiating between various forms of uveitis. Both imaging techniques may be helpful in monitoring patients with uveitis over time.


Optical coherence tomography (OCT) and fundus autofluorescence (FAF) are two technologies widely used to image a variety of retinal diseases. OCT permits 3D evaluation of the retina,[1] while FAF enables evaluation of attributes of the outer retina and retinal pigment epithelium (RPE) that are otherwise invisible on biomicroscopic examination.[2] In uveitis, these imaging techniques help evaluate retinal structure and function. Cystoid macular edema and epiretinal membrane formation are common in many forms of uveitis, and OCT can be helpful to both diagnose and monitor these conditions.[3] In addition, OCT and FAF are able to detect specific alterations that are often unique to particular diseases, and they can also be used to monitor disease progression. This article will focus on OCT and FAF findings specific to posterior uveitis.