The Role of Obesity and Type 2 Diabetes Mellitus in the Development of Male Obesity-associated Secondary Hypogonadism

S. A. Saboor Aftab; S. Kumar; T. M. Barber


Clin Endocrinol. 2013;78(3):330-337. 

In This Article


To conclude, MOSH should be viewed as a distinct subtype of male SH in obese men. The pathogenesis of MOSH is complex and is likely to implicate both obesity-related and, in the cases of T2DM and OSA, nonobesity-related factors. It is clear that there are close associations between sleep, metabolism, glycaemia, obesity and HPT function in men and that these associations may include causal pathways which manifest bidirectionality. Future studies should focus on gaining a clearer understanding of these interlinked pathways. This in turn would inform the development of novel therapeutic strategies for the future management of MOSH. Ultimately, such important research would be expected to improve the long-term sexual, metabolic, bone, CV and mental health of men who develop MOSH, and as such would be clinically well justified.