Study (year) |
Type of study |
group |
Treatment |
Subjects (n) |
Mean diameter (cm) |
Bilateral (%) |
AMH (ng/ml) |
Ref. |
Cystectomy |
Kitajima et al. (2011) |
Prospective cohort |
Ovarian cyst |
OE, cystectomy† (group 1) |
19 |
6.7 ± 1.9 |
Unilateral only |
-1.25 (MD), -24.6%D |
[113] |
|
|
|
Non-OE cyst, cystectomy (group 2) |
13 |
6.8 ± 2.1, NS, group 1 vs 2 |
Unilateral only |
3.3%D; p = 0.02, group 1 vs 2 |
|
Ercan et al. (2010) |
Prospective cohort |
OE, no prior surgery |
Cystectomy†, unilateral OE (group 1) |
33 |
0.59 ± 0.08 |
Unilateral only |
-0.79 (MD) |
[98] |
|
|
|
Cystectomy†, bilateral OE (group 2) |
14 |
0.86 ± 0.11 |
Bilateral only |
-0.27 (MD); NS, group 1 vs 2 |
|
|
|
|
Control – fertile, no OE (group 3) |
12 |
|
|
2.06 ± 0.51; NS, group 2 vs 3 (baseline and follow-up) |
|
Biacchiardi et al. (2011) |
Prospective cohort |
Normo-ovulatory and OE |
Cystectomy† |
43 |
3.68 ± 1.08 |
23.30% |
-1.7 (MD); p < 0.001 |
[56] |
Ercan et al. (2011) |
Prospective cohort |
OE, no prior surgery |
Cystectomy† |
36 |
5.2 ± 1.4 |
Unilateral only |
-0.08 (MD), NS |
[112] |
Lee et al. (2011) |
Prospective cohort |
OE, no prior surgery |
Cystectomy† |
13 |
4.0 ± 1.8 |
Unilateral only |
-1.4 (MD); p < 0.002, baseline vs follow-up |
[114] |
Hirokawa et al. (2011) |
Prospective cohort |
OE, no prior surgery |
Cystectomy†, unilateral (group 1) |
20 |
6.1 ± 2.5 |
Unilateral only |
-1.2 (MD) |
[99] |
|
|
|
Cystectomy†, bilateral (group 2) |
18 |
6.7 ± 1.8, p = 0.125, group 1 vs 2 |
Bilateral only |
-2.4 (MD); p < 0.001, group 1 vs 2 |
|
Cystectomy versus three-stage technique |
Tsolakidis et al. (2010) |
Prospective, randomized controlled trial |
OE, no prior surgery |
Cystectomy† (group 1) |
10 |
3.79 ± 0.48 |
Unilateral only |
-1 (MD); p = 0.026, baseline vs follow-up |
[61] |
|
|
|
Three-step (group 2) |
10 |
3.68 ± 0.55 |
Unilateral only |
-0.51' NS, baseline vs follow-up, p = 0.026, group 1 vs 2 |
|
Aspiration with sclerotherapy |
Yazbeck et al. (2009) |
Prospective |
Infertile and recurrent OE |
Aspiration with 95% EST (group 1) |
31 |
3.86 ± 1.12 |
12.90 |
3.1 ± 2 |
[68] |
|
|
|
Contro – Stage III/IV endometriosis, no OE (group 2) |
26 |
|
|
2.2 ± 2.9; p = 0.03, group 1 vs 2 |
|
Shawki et al. (2012) |
Prospective case–control |
Infertile and OE |
Aspiration with MT |
65 |
6.5 ± 1.53 |
Unilateral only |
3.3 ± 0.4 |
[71] |
Expectant management versus traditional treatments |
Hwu et al. (2011) |
Retrospective |
Tubal or male infertility (group 1) |
No treatment |
1323 |
|
|
3.94 (≤30 years old), 3.31 (31–35 years), 1.98 (≥36 years) |
[37] |
|
|
In situ OE, no prior surgery (group 2) |
No treatment |
141 |
≥3 cm (mean not reported) |
22.60 |
2.97 (≤30 years old); p < 0.05, group 1 vs 2; 2.34 (31–35 years); p < 0.001, group 1 vs 2; 1.35 (≥36 years); p < 0.05, group 1 vs 2 |
|
|
|
Unilateral (group 2a) |
|
109 |
|
|
2.45 ± 0.17 |
|
|
|
Bilateral (group 2b) |
|
32 |
|
|
1.56 ± 0.24; p < 0.05, group 2a vs 2b |
|
|
|
Prior cystectomy OE (group 3) |
Prior cystectomy |
147 |
≥3 cm (mean not reported) |
44.90 |
1.74 (≤30 years old); p < 0.001, group 1 vs 3; p < 0.05, group 2 vs 3; 1.53 (31–35 years); p < 0.001, group 1 vs 3, p < 0.05, group 2 vs 3; 0.53 (≥36 years); p < 0.001, group 1 vs 3; p < 0.05, group 2 vs 3 |
|
|
|
Unilateral (group 3a) |
|
81 |
|
|
1.48 ± 0.14 |
|
|
|
Bilateral (group 3b) |
|
66 |
|
|
1.01 ± 0.11; p < 0.05, group 3a vs 3b |
|
|
|
In situ OE cystectomy (group 4) |
Cystectomy† |
31 |
≥3 cm (mean not reported) |
Unilateral only |
-1.94 (MD); p < 0.01 |
|