The use of pHWF for allergic disease prevention is controversial with a long and chequered history. Only if pHWF is proven to be protective against the development of clinical disease should it be recommended. The evidence concerning the effect of these formulae is mixed, and there are a number of important methodological limitations described here that have not been fully taken into consideration in formulating the existing guidelines. Given these significant methodological limitations, and recently published evidence, updating of systematic reviews and existing guidelines on the use of pHWF for allergic disease prevention is warranted and timely. Until more definitive evidence is obtained, overstating the potential for pHWF to prevent allergic disease should be avoided, and we recommend continuing to advocate that 'breast is best'.
Expert Rev Clin Immunol. 2013;9(1):31-41. © 2013