CoQ10 and L-carnitine for Statin Myalgia?

James J DiNicolantonio


Expert Rev Cardiovasc Ther. 2012;10(10):1329-1333. 

In This Article

Five-year View

Switching patients who are experiencing muscle pains on simvastatin to pravastatin seems to be a reasonable approach, especially considering the fact that carriers of the SLCO1B1*5 allele do not have myalgias while on pravastatin.[15] Further trials may lead us to genetic tests that can rule out certain underlying causes of 'statin myalgia' and allow clinicians to treat the root condition, which was brought out by the use of a statin. In current practice, CoQ10 seems to be a safe and reasonably effective supplement for treating statin myalgias. Larger randomized trials should be performed to confirm the results of CoQ10 and prove the concept of l-carnitine, as a treatment for statin myalgia.