CoQ10 and L-carnitine for Statin Myalgia?

James J DiNicolantonio

Disclosures

Expert Rev Cardiovasc Ther. 2012;10(10):1329-1333. 

In This Article

Conclusion

In summary, it has been proposed that CoQ10 can help to treat statin myalgia. While this is not conclusive, there are two randomized controlled trials showing significant improvements in the severity of muscle pain with the use of CoQ10 in patients treated with statins. Thus, it is not unreasonable to supplement a patient who is experiencing muscle pains on a statin with CoQ10. While there are no clinical trials showing improvements in muscle pain with the use of l-carnitine, patients who experience statin myalgia frequently have carnitine abnormalities. It is too soon to recommend l-carnitine for statin myalgia, but future trials should test this supplement to see if it has any place for this adverse effect. Other common alternatives for treating statin myalgias are supplementation with vitamin D or vitamin B12, especially in the setting of suboptimal serum levels.

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