Treatment Options for Advanced Pancreatic Cancer

A Review

Rahma Warsame; Axel Grothey


Expert Rev Anticancer Ther. 2012;12(10):1327-1336. 

In This Article

Five-year View

The future treatment of pancreatic cancer will incorporate multiple oncogenic targets combined with chemotherapy; this treatment strategy may occur concurrently or sequentially. Identification of more treatment targets is important to developing more potential agents. Future clinical trials will focus on these combinations and how best to incorporate and administer them.

Clearly, a better understanding of the biology of pancreatic cancer cells, their interaction with the host environment, and the discovery of actionable molecular alterations will be imperative to develop more active therapeutic approaches. In addition, determining predictive factors for newly developed agents will be vital to achieving significant success. Predicting response to different therapies in patients may allow for individualizing care. Ultimately, earlier diagnosis, more aggressive treatments following resection and identifying prognostic markers in biopsies are necessary to significantly improve outcomes. Now that the pancreatic cancer genome has been sequenced, identifying the mutations and targeting those specific mutations to tailor treatment to the patient may be possible in the future.