The Psoriatic Keratinocytes

Zsuzsanna Bata-Csörgö; Marta Szell

Disclosures

Expert Rev Dermatol. 2012;7(5):473-481. 

In This Article

Abstract and Introduction

Abstract

Psoriasis is an inflammatory skin disease with characteristic changes in the epidermis that resembles unsuppressed wound healing due to excessive hyperproliferation of keratinocytes. The keratinocyte hyperproliferation is also accompanied by abnormal differentiation of cells. It is not clear how much keratinocytes contribute to disease pathology. In this article, the authors, however, attempt to summarize data that argue for the importance of abnormal keratinocyte behavior in the pathomechanism of psoriatic skin lesions.

Introduction

Psoriasis is a multifactorial disease which shows polygenic inheritance and affects the skin and joints. It is a common disease with a prevalence of up to 2–3% in many populations. Although the pathogenesis of psoriasis is not completely known, numerous studies indicate that immune dysregulation plays an essential role in disease development. As in other multifactorial diseases, the clinical manifestation of the disease has a wide range. The most common type is the plaque type of psoriasis, in which sharp-edged lesions develop on the otherwise normal-looking skin. On histological examination of the psoriatic lesional skin, besides inflammation, hallmark characteristics are hyperproliferation and abnormal differentiation of keratinocytes. In recent years, epidemiological studies indicate that psoriasis is a more systemic disease than previously believed, metabolic syndromes including atheromatous cardiovascular changes are more frequent in patients with psoriasis.[1,2]

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