Psychiatric Drug-Drug Interactions

A Refresher

Tammie Lee Demler, BS, PharmD, MBA, BCPP


US Pharmacist. 2012;37(11):HS-16-HS-19. 

In This Article


Chronic coadministration of psychiatric drugs with known interaction potential can be safely managed with dose changes, therapeutic interchanges with similar products, and/or administration time adjustments. Newly initiated combinations are the highest risk for adverse effects from drug interactions; thus, first-dose monitoring is essential, along with the patient's own personal report of the perceived benefit and side effects of therapy. When considering drug-drug interactions with psychiatric agents, practitioners and prescribers should consider the following survival tips:[3]

  • Become an expert in the drugs used most often in one's own practice

  • Pay special attention to those drugs with narrow therapeutic indices and potential lethal doses

  • Consult resources frequently

  • Try to select agents that have a low degree of drug-interaction potential.