Research Advances With Regards to Clinical Outcome and Potential Mechanisms of the Cholesterol-Lowering Effects of Probiotics

Guo Zhuang; Xiao-Ming Liu; Qiu-Xiang Zhang; Feng-Wei Tian; Hao Zhang; He-Ping Zhang; Wei Chen


Clin Lipidology. 2012;7(5):501-507. 

In This Article

Future Perspective

The structure of the human gut microbiota is associated with human health, particularly the incidence of gastrointestinal diseases.[43,44] Using multiplexed-454 barcoded pyrosequencing of the 16S rRNA gene, Koren et al. found that the abundance of Fusobacterium, Neisseria and Streptococcus in the oral cavity, and Erysipelotrichaceae and Lachnospiraceae families in the gut, was correlated with levels of cardiovascular disease markers.[45] Some reports indicated that probiotic intervention can reduce the prevalence of oral Candida and Streptococcus mutans in saliva of subjects,[46,47] as well as altering the intestinal microflora balance.[48] Therefore, one mechanism by which probiotics are thought to lower cholesterol is via an effect on the balance of oral cavity and intestinal microflora, however, this viewpoint is only a hypothesis. In the future, with the emergence and development of new molecular methodologies, the relationship between microbial make-up and disease, or the possibility to treat some diseases through a change in the composition of gut microbes by administration of oral probiotic strains, will lead to better understanding and verification.