Research Advances With Regards to Clinical Outcome and Potential Mechanisms of the Cholesterol-Lowering Effects of Probiotics

Guo Zhuang; Xiao-Ming Liu; Qiu-Xiang Zhang; Feng-Wei Tian; Hao Zhang; He-Ping Zhang; Wei Chen


Clin Lipidology. 2012;7(5):501-507. 

In This Article


Although there is some clinical evidence for the role of probiotics in lowering cholesterol, the results are conflicting. In order to evaluate the varying cholesterol-lowering effects exhibited by probiotics, researchers have investigated the mechanisms by which probiotics affect hypercholesterolemia through in vitro and in vivo studies. The accepted mechanisms are the inhibition of absorption through cholesterol binding by and incorporation in bacterial cells, and through the suppression of bile acid reabsorption mediated by bacterial bile salt hydrolysis. Recent research has indicated that probiotics appear to regulate the expression of the NPC1L1 protein, HMGCoA reductase, and 7α-, 27α-hydroxylase, but these mechanisms are still not fully understood.