Hyperthyroidism and Erectile Dysfunction

A Population-Based Case-Control Study

J Keller; Y-K Chen; H-C Lin


Int J Impot Res. 2012;24(6):242-246. 

In This Article


Of the 25 240 sampled subjects, the mean age was 52.1 years, with a standard deviation of 14.4 years. The distribution of demographic characteristics and co-morbidities for cases and controls are presented in Table 1. After matching for age group and urbanization level, cases were found to be more likely to reside in the northern part of Taiwan (P<0.001) and have a higher monthly income of ≥NT$25 001 (P<0.001) than controls. Cases had a higher prevalence of hyperlipidemia (25.9% vs 16.6%, P<0.001), diabetes (22.3% vs 12.9%, P<0.001), hypertension (36.3% vs 27.0%, P<0.001), coronary heart disease (15.4% vs 9.2%, P<0.001) and obesity (0.4% vs 0.2%, P=0.003) compared to controls. There was no significant difference in the distribution of alcohol abuse/alcohol dependence syndrome between cases and controls (P=0.630). In addition, Table 1 further illustrates the results of several post-hoc analyses conducted on the variables of monthly income and geographic region adjusting for alpha error by the Bonferroni correction.

Table 2 presents the distribution of ORs of prior hyperthyroidism between cases and controls. In total, 569 (2.3%) of the 25 240 sampled subjects had been diagnosed with hyperthyroidism before the index date; hyperthyroidism was found in 207 (3.3%) cases and 362 (1.90%) controls. Conditional logistic regression analysis (conditioned on age group, urbanization level and index year) revealed that cases were 1.74 (95% confidence interval=1.46–2.07; P<0.001) times more likely to have been previously diagnosed with hyperthyroidism. After adjusting for monthly income, geographic location, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity and alcohol abuse/alcohol dependence syndrome, conditional logistic regression further revealed that the OR of prior hyperthyroidism among cases was 1.64 (95% confidence interval=1.37–1.96, P<0.001) than that of controls.

Furthermore, Table 3 and Figure 1 shows the results of analyses for prior hyperthyroidism stratified by age group. No association was detected between prior hyperthyroidism and ED for the 18–30, 30–39 and ≥70 age groups. Subjects aged between 60 and 69 years had the highest ORs for prior hyperthyroidism among cases when compared to controls (OR=1.84; 95% confidence interval=1.20–2.84; P<0.001).[3,14]

Figure 1.

Mean and 95% confidence interval of odds ratios for hyperthyroidism among patients with erectile dysfunction by age group.