Androgen Replacement Therapy in Women

Marie Lebbe; David Hughes; Nicole Reisch; Wiebke Arlt


Expert Rev Endocrinol Metab. 2012;7(5):515-529. 

In This Article

Expert Commentary

Current evidence supports that woman with severe androgen deficiency, as observed in bilateral oophorectomy and adrenal insufficiency, benefit from androgen replacement with regard to improvement of sexual function and quality of life. The relationship between circulating androgen levels and sexual function and mood in women with normal ovarian and adrenal function needs to be further established, with comprehensive studies employing sensitive testosterone assays and valid reproducible questionnaires. Further clinical studies focusing on long-term consequences and safety of androgen treatment in women are needed to support firm recommendations.