Probiotics for the Prevention and Treatment of Clostridium difficile in Older Patients

Jasmin Islam; Jonathan Cohen; Chakravarthi Rajkumar; Martin J. Llewelyn


Age Ageing. 2012;41(6):706-711. 

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Search Strategy and Selection Criteria

A search of BioMed Central Journals, Cochrane Library—Cochrane Database of Systematic Reviews (Wiley), Global Health (Ovid Technologies), MEDLINE (CSA), PubMed, SCOPUS-V.4 (Elsevier) and Web of Knowledge was conducted during March 2012. Keywords included: probiotic, Clostridium difficile, AAD, intestinal microflora, immunesenescence, elderly. References were searched by hand and further relevant papers identified from their citations. The pubmed search identified 37 original papers describing the use of probiotics in AAD or CDI with seven additional papers identified manually. From these, 16 original research papers describing intervention studies were identified and included in the review.