Probiotics for the Prevention and Treatment of Clostridium difficile in Older Patients

Jasmin Islam; Jonathan Cohen; Chakravarthi Rajkumar; Martin J. Llewelyn


Age Ageing. 2012;41(6):706-711. 

In This Article


There has never been a trial investigating probiotics as the sole treatment for CDI. A Cochrane systematic review looked at four studies investigating the use of probiotics as an adjunct to first line conventional antibiotic treatment.[46] Only one study showed patients treated with S. boulardii were statistically less likely to experience a relapse of CDI versus placebo (RR: 0.59; 95% CI: 0.35–0.98).[41] The remaining studies were too small to draw any significant conclusions. The authors concluded that no recommendation can be made for the use of probiotics as treatment for CDI.