Evaluation of Documented Drug Interactions and Contraindications Associated With Herbs and Dietary Supplements

A Systematic Literature Review

H.-H. Tsai; H.-W. Lin; A. Simon Pickard; H.-Y. Tsai; G. B. Mahady


Int J Clin Pract. 2012;66(11):1056-1078. 

In This Article


This review provides a structured summary of the evidence of the most widely documented HDS interactions and contraindications with medications. Although our findings primarily concern with a relatively small subset of commonly used medications and HDS entities, it is recommended that healthcare professionals should be paid more attention towards those pairs of interactions between any HDS products that contain St John's Wort, magnesium, calcium, iron and ginkgo, and medications that affect the CNS or the cardiovascular system. These findings should be helpful for healthcare professionals to identify the priority areas where communication regarding HDS usages has the greatest potential to prevent adverse events and to improve patient's therapeutic outcomes.