Eosinophilic Gastroenteritis

An Update

Alfredo J Lucendo; Angel Arias


Expert Rev Gastroenterol Hepatol. 2012;6(5):591-601. 

In This Article

Natural History of EGE

In spite of the approximately 400 EGE cases described in the literature, very few series have focused on elucidating its natural history. A recently published French study analyzed the clinical characteristics and evolution of 43 adult patients with EGE who were followed for a mean period of 13 years.[13] The authors described three different evolutionary patterns (Figure 1): 42% of patients suffered a single outbreak of EGE lasting <3 months; 37% of patients exhibited a recurrent pattern of disease, with an average of 5.2 flare-ups during extremely variable intervals and finally 21% of patients had a continuous disease course with persistent symptoms. No additional studies have determined the global relapse rate after the first flare. High eosinophil blood counts at the time of diagnosis were associated with an increased risk of disease recurrence.[13] There was no tumor or myeloproliferative transformation in any patient during follow-up. In fact, an association between EGE and malignancy has only been described once in the literature in a case study of a 69-year-old Japanese man with multiple gastric cancer and EGE who responded well to a total gastrectomy and prednisolone treatment.[100]

Figure 1.

Types of evolution of eosinophilic gastroenteritis. After a mean follow-up period of 13 years, de Chambrun et al. identified different types of evolution of EGE [13]. (A) Patients with a single outbreak of disease without recurrence (42% of cases). (B) Patients with a recurrent course characterized by multiple outbreaks and periods of complete remission lasting from 2 months to several years (37% of cases) and (C) patients with a continuous course (21% of cases). EGE: Eosinophilic gastroenteritis. Reproduced with permission from [13].